Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors

Blog Article

Extrachromosomal DNA is a common cause of oncogene amplification in cancer.The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, is incompletely understood.

We examined gene expression patterns of 870 tumors of varied Plastic Car histological types, to identify transcriptional correlates of ecDNA.Here, we show that ecDNA-containing tumors impact four major biological processes.Specifically, ecDNA-containing tumors up-regulate DNA damage and repair, cell cycle control, and mitotic processes, but down-regulate global immune regulation pathways.

Taken together, these Kratom Capsules results suggest profound alterations in gene regulation in ecDNA-containing tumors, shedding light on molecular processes that give rise to their development and progression.